An Innovative Approach for Delivery of Nanosized Duloxetine Via External Acoustic Meatus (EAM) Platform

  • Deepika Raina
  • Satheesh Madhav Novel Research Lab Dehradun Institute of Technology, Makkawala,P.O Bhagwantpura-248009,Dehradun, Uttrakhand, India
Keywords: Acoustic meatus, nano-suspension, Higuchi matrix, anomalous transport


Objective: Depression is a common but serious mood disorder. The treatment cost is very high. The external auditory canal is used as a delivery platform and has overcome the dose dumping problem in the case of oral system. The current research work was to explore a novelistic route for targeting to the brain through ear by formulating nanosuspension using duloxetine as a model drug permitting better control over depression. Method: The concept was proved by preparing a nano-sized formulation of API i.e duloxetine and observed its pharmacological actions by sonication bath method. Bio-nano suspension was prepared by using a biopolymer which was isolated from berries of Piper nigrum. Eight formulations were prepared viz 1:0.5, 1:1, 1:2, 1:3, 1:4, 1:5, 1:7, and 1:10. Results: The formulations were subjected to various evaluations, including pH, % transmittance, content uniformity, ex-vivo stability, release for over 36 hours. Different formulations of duloxetine out of which F1 (1:0.5) was found to be the best formulation having the r2 value of 0.9905 tT80: 22 hrs and the best fit model was found to be Higuchi matrix, and mechanism of transport was anomalous transport which was calculated by bits software. Conclusion: On the basis of the in-vitro results obtained it can be concluded that significant amount of drug reaches the brain via external acoustic meatus and so it is feasible to deliver Duloxetine by this novelistic route.

References on 3 march 2017.

Weerda, H. Surgery of the auricle: tumors, trauma defects, abnormalities. New York: Thieme.2007

Yasutoyo Ikari, et al. Fetal development and variations in the cartilages surrounding the human external acoustic meatus. Annals of Anatomy. 2013; 195, 128–36

Mallo, M., et al. Assembling a functional tympanic membrane: signals from the external acoustic meatus coordinate development of the malleal manubrium development. 2000;127, 4127–36.

Richard Drake, A. Wayne Vogl, Adam Mitchell. Gray's Anatomy for Students, 3rd Edition, Drake 1-2 chapter 8, 21 Feb 2014

Karpa ; Anttila and Leinonen et al. An XML based ontology exchange language.2002;3,1217-21

Georgianna G. Gould et al. Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biol psychiatry. 2007; 61, 210–5

Michael Paulzen et al. Duloxetine enters the brain – But why is it not found in the cerebrospinal fluid. Journal of Affective Disorders. 2016; 189, 159–63

Pallavi Yerramsett et al. Formulation, Development and Evaluation of delayed release capsules of Duloxetine Hydrochloride made of different Enteric Polymers. Int. J. Drug Dev. & Res., Jan-March 2012, 4: 117-29

Madhav NS, Jaiswal V, Ojha A. Development and evaluation of nanosized aripiprazole-loaded bioflexy films using a biopolymer from Lagenaria siceraria for brain delivery through orosoft palatal mucosal platform. Egyptian Pharmaceutical Journal. 2017;16:62.

Original Research