Capecitabine Induced Therapy Related Acute Myeloblastic Leukemia with t(10;11) (q22;q23) in a Patient with Breast Cancer

  • Zübeyde Nur Özkurt Gazi Üniversitesi Tıp Fakültesi
  • Ramazan Öcal Gazi Üniversitesi Tıp Fakültesi
  • Mehmet Sezgin Pepeler Gazi Üniversitesi Tıp Fakültesi
  • Burcu Ülküden Gazi Üniversitesi Tıp Fakültesi
Keywords: Capecitabine, therapy related acute myeloblastic leukemia, breast cancer, t(10, 11)(q22, q23)

Abstract

Capecitabine is an oral agent that is used either as single agent or in combination therapy. Therapy related acute myeloblastic leukemia after capecitabine use is rarely reported. We presented a 39-year-old woman with metastatic breast cancer. She admitted with acute myelomonocytic leukemia after treating with oral Capecitabine. t(10;11)(q22;q23) was determined in conventional cytogenetic analysis. She achieved complete remission with intensive chemotherapy but relapse developed. She died although the salvage chemotherapy. To our knowledge our patients is the first report with t-AML with t(10;11)(q22;q23) secondary to Capecitabine use for breast cancer treatment. Capecitabine should be carefully used especially in patients with high risk for t-AML.

Author Biographies

Zübeyde Nur Özkurt, Gazi Üniversitesi Tıp Fakültesi
Hematoloji BD Doç. Dr.
Ramazan Öcal, Gazi Üniversitesi Tıp Fakültesi
Hematoloji BD Uzm. Dr.
Mehmet Sezgin Pepeler, Gazi Üniversitesi Tıp Fakültesi
Hematoloji BD Uzm. Dr.
Burcu Ülküden, Gazi Üniversitesi Tıp Fakültesi
Hematoloji BD Uzm. Dr.

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Published
2017-12-22