Impact of Pulmonary Embolism on Acute Chronic Obstructive Pulmonary Disease Exacerbation

  • Murat Türk Erciyes University School of Medicine
  • Fatma Yıldırım Gazi University School of Medicine
  • Nurgül Sevimli Gazi University School of Medicine
  • Nurdan Köktürk Gazi University School of Medicine
Keywords: Pulmonary embolism, chronic obstructive pulmonary disease, exacerbation


Purpose: This study aims to assess effect of pulmonary embolism (PE) on clinical and laboratory parameters of patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (AECOPD). Risk factors for PE development were also evaluated.Methods:In this retrospective study, patients who were hospitalized for AECOPD and underwentcomputed tomographic pulmonary angiography scan (CTPA) between 2009 and 2011 were included. Patients with PE were evaluated separately as those diagnosed at initial examination and those suspected during exacerbation therapy since they had inadequate response. Binary logistic regression analysis was used in order to determine risk factors on PE development.Results: The study consisted of 36 patients, 13 patients (36.1%) had PE. FEV1 and FEV1/FVC values were higher in PE group (53.7% vs 41.4%; 62.3% vs 52% respectively; p<0.05). There was no difference between D-dimer levels of PE and non-PE patients. Risk of PE development did not differ with analyzed variables. Those diagnosed at initial examination had significantly less number of exacerbations in the last one year than those diagnosed during therapy (1.1 vs 3.2; p<0.05).Conclusion:PE should always be considered inAECOPDetiology, particularly in patients with frequent exacerbation history and D-dimer levels may bemisleading.

Author Biographies

Murat Türk, Erciyes University School of Medicine
Department of Chest Diseases, Division of Allergy and Clinical Immunology
Fatma Yıldırım, Gazi University School of Medicine
Department of Chest Diseases
Nurgül Sevimli, Gazi University School of Medicine
Department of Chest Diseases
Nurdan Köktürk, Gazi University School of Medicine
Department of Chest Diseases


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Original Research