Kantaron Ekstresinin Gentamisinin Neden Olduğu Ototoksisite Üzerinde Koruyucu Etkisi

  • Halil Mahir Kaplan

Abstract

Amaç: Hypericum perforatum tarla, yol ve orman kıyılarında, tepelerde ve çayırlarda Temmuz'dan Eylül'e kadar çiçeklenen ve ülkemizde, sarı kantaron, kanotu, kılıçotu, mayasilotu ve yaraotu gibi adlara sahip ve bazı hastalıklara karşı yöresel insanlar tarafından kullanılan bitkidir ve yapılan çalışmalarda anti inflamatuar ve antioksidant etkinliği gösterilmiştir.  Bu nedenle kantaron bitkisinin gentamisin ile oluşturulan ototoksisite üzerinde koruyucu etkinliği olup olmayacağını planladık.Yöntem: Bu amaçla ferelere 9 gün 100 mg/kg gentamisin ve gentamisinle birlikte 70 mg/kg kantaron ekstresi verildi. 9. ve 10. günlerde gentamisinin ve kantaron ekstraktının farelerin motor koordinasyonunu üzerine etkisini değerlendirmek için rotarod testi uygulandı.Bulgular: Gentamisin uygulaması farelerin düşüş süresini azalttı. Gentamisin ile birikte kantaron ekstaktı verilmesi bu süreyi uzattı.Sonuç: Çalışmamız gentamisinin neden olduğu ototoksisiteyi önlemede yararlı olacağını göstermiştir.

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Published
2016-12-26
Section
Original Research